The invention discloses a mass production compound fertilizer of datura metel. The compound fertilizer is prepared from the following components in parts by mass: 20-35 parts of night soil, 20-30 parts of phosphate fertilizer, 10-25 parts of dry weed powder, 2-5 parts of agricultural rare earth, 11-18 parts of peanut straw, 12-20 parts of plant ash, 10-22 parts of calcium superphosphate, 7-10 parts of carbamide, 3-10 parts of potassium sulfate, 10-15 parts of ferrous chloride, 2-6 parts of ammonium molybdate and 3-5 parts of borax. The compound fertilizer can effectively improve the growth environment of the datura metel, increase growth speed of plants, increase the yield, effectively improve the anti-acidification hardening capacity of soil and ensure the continuous production capacity.