The application relates to a substation five-anti- interlocking method, a substation five-anti- interlocking device, computer equipment, and a storage medium. The method comprises the following steps:obtaining an operation command for an analog power component on a main wiring diagram, wherein the operation command carries power component information, and the analog power component on the main wiring diagram comprises: a switch, a ground knife, a bus bar, a switch, a line and a handcart; and performing corresponding interlocking logic detection based on the power component information. The method can avoid the problem of manual logic detection being error-prone.