The embodiment of the invention discloses a three-dimensional image region contour generation method based on GPU parallel acceleration. The method comprises the steps that region contour pixel sets in a left view image, a right view image and a left view image are given; obtaining robust matching feature pixel set pairs according to a GPU accelerated scale invariant feature conversion and randompomelo sample consistency inspection method; performing edge line uniform sampling to obtain an edge sampling pixel set in the left view image; obtaining a triangularized pixel set in the left view image through additional random sampling; according to a Delaunay triangularization method accelerated by the GPU, calculating a planar triangular mesh of the left view image; obtaining a triangularizedpixel set in the right view image by using a GPU accelerated conjugate gradient method; and calculating an area contour pixel set in the right view image, wherein a closed loop line formed by the area contour pixel set is an area contour line result in the right view image. By implementing the method and the device, the parallelism of regional contour line generation can be effectively improved,and the calculation efficiency is improved.