The invention discloses a lotion containing a heparin-like composition, and belongs to the field of biotechnology. The lotion containing the heparin-like composition is characterized by comprising 0.01-30 parts of mucopolysaccharide, 0.01-5 parts of a transdermal absorbent, 0.01-5 parts of an antioxidant, 0.01-5 parts of a bacteriostatic agent, 0.01-15 parts of a surfactant and 0.01-5 parts of a preservative. Under a synergistic action of a keratin softening agent and the natural moisturizing agent, the lotion containing the heparin-like composition can inhibit excessive growth of collagen fiber and reduce scar formation; the lotion containing the heparin-like composition can retain moisture on the surface of skin to soften the collagen fiber and enhance the elasticity and has an effect ofsoftening a hypertrophic scar.