The invention discloses a production technology of a cotton-polyester plume escape-preventing fabric with high count and high density. The production technology comprises the following steps of selecting of materials, warping, sizing of yarns, drafting and reeding, weaving, pretreatment before dyeing and finishing, dyeing, wind-proof arrangement, foam shaping, coiling, packaging, and delivery intoa warehouse; 40-80S long staple combed cotton yarns are used as warp yarns, and 80-120D superfine and porous luster polyester long yarns are used as weft yarns; the cotton-polyester fabric is dyed bya one-bath and two-step method. The production technology of the cotton-polyester plume escape-preventing fabric with high count and high density has the characteristics that the 40-80S long staple combed cotton yarns are used as the warp yarns, so that the evenness of the warp yarn is good, the hand feel is soft, and the strength is high; the fabric weaved by the yarns with smaller diameter haslight weight; compared with common polyester long yarns, the superfine and porous luster polyester long yarn is porous, so that the moisture absorbing property and air ventilating property are improved; at the premises of no reduction of breathability and the like of the plume escape-resistant fabric, the cost of the plume escape-resistant fabric is reduced.