The invention provides an enameled wire, which comprises a conductor core wire and an insulating coating wrapping the conductor core wire, wherein the insulating coating comprises a polyesterimide lacquer coating and a fluorosilicone lacquer coating, the fluorosilicone lacquer coating is arranged on the polyesterimide lacquer coating; and the fluorosilicone lacquer coating is prepared by the following raw materials in parts by weight: 50-60 parts of fluorosilicone resin, 10-15 parts of glass fibers, 5-8 parts of lapis chloriti, 1-3 parts of isothiazolinone and 40-60 parts of glycerol. The enameled wire provided by the invention has the effects of high temperature resistance, high corrosion resistance, good electrical insulation property and the like. The invention further provides a preparation process of the enameled wire, the process is simple, the production processing efficiency is high, and the lacquer layer continuity and saline pinholes of the obtained enameled wire are extremely few.