The invention relates to a gas chromatography-mass spectrum interface sealing compression ring compression device. The device comprises a connection body, a mandril, an amplitude limiting nut and a gasket, and is used for compressing a sealing compression ring at a junction between a capillary chromatographic column (chromatographic column for short and similarly hereinafter) and the interface, soas to realize sealing at the interface between a vacuum system and external air. The device is characterized in that the connection body is connected with each of the interface and the mandril; a groove is formed in the axial direction of the mandril; a boss is arranged at one end of the mandril; the boss pushes the gasket and a sealing compression ring to the interface to realize sealing; and the amplitude limiting nut is screwed at the head of the mandril to limit the swing amplitude of the chromatographic column. The device is effective in sealing, and is capable of preventing metal heavyobject such as nuts and the like from acting on the chromatographic column to damage and even break the chromatographic column when the chromatographic column is dismounted.