The invention discloses a medicine for treating leucoderma. The medicine for treating leucoderma is prepared from the following raw materials: radix aconiti carmichaeli, radix paeoniae rubrathe, coxtex moutan, caulis kadsurae, cantharides, monkshood, semen astragali complanati, resina liquidamberis, chinese arborvitae twig, radix sileris, conyza blinii, herba hyperici perforati, peach juvenile branchlet, campsis grandiflora lois, chinese starjasmine stem, kadsura longepedunculata, semen allii tuberosi, rhododendron simsii, radix astragali, lotus plumule, nidus vespae, storax, pericarpium citrireticulatae viride and licorice root. The medicine does not have toxic or side effects, is reasonable in compatibility, fast in curative effect, and stable in efficacy, and has a good curative effect, moreover, the medicines are convenient to obtain, damage of internal medicines and injected medicines to the stomach, the intestine, the liver and the kidney is avoided, and leucoderma can be treated fundamentally, and does not have a relapse.