The invention discloses a prestress assembled frame structure tensioned and anchored on column brackets. A frame beam and frame columns are horizontally connected by frame column brackets in middles of the frame columns, and the frame columns are vertically connected by column end brackets at ends of the frame columns; the prestress assembled frame structure is applicable to simplified connectingstructures with excellent performance between the beam and the columns and between the columns, the beam and the columns are connected through brackets bulging around the middles of the columns, prestressed tendons are tensioned and anchored on the brackets to realize mutual connection, so that tensioning and anchoring operation of the assembly prestressed tendons is facilitated, load-bearing steel bars and node assembly steel bars are combined, and steel bar consumption is reduced. The columns are connected nearby the middle of a floor, the brackets bulge around upper and lower connecting ends, oblique prestressed connecting steel bars are tensioned and anchored on the brackets, connection of the columns is facilitated, and connection interfaces can be ensured to have good shear resistance and bending strength.