The invention discloses an Onepass printing control method, device and equipment and a medium. According to the Onepass printing control method, device and equipment and the medium, common physical channels and special physical channels in all physical channels are confirmed according to a printing requirement; n logical channels are arranged for each common physical channel, and y logical channels are arranged for each special physical channel; a printing command is received, and with the logical channels as units, corresponding printing data are extracted from a printing memory; according toprinting parameters, the printing data corresponding to all the logical channels in each common physical channel are combined and then are processed to be input into the common physical channel for printing; and meanwhile according to the printing parameters, the printing data corresponding to the logical channels of each special physical channel are directly processed and input into the specialphysical channel for printing. The Onepass printing control method, device and equipment and the medium guarantee independent control of all production lines.