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发明公开
CN109620822A 一种用于治疗人恶性脑胶质瘤或黑色素瘤的番荔枝种子提取物及其制备方法和应用 无效 - 驳回

一种用于治疗人恶性脑胶质瘤或黑色素瘤的番荔枝种子提取物及其制备方法和应用
摘要：
本发明提供了式Ⅰ、式Ⅱ和式Ⅲ中任意一项或多项所示化合物在制备治疗脑胶质瘤或黑色素瘤的药物中的应用，属于肿瘤药物技术领域。本发明所述式Ⅰ、式Ⅱ和式Ⅲ所示化合物为番荔枝总内酯提取物中的单体成分。本发明还提供了一种用于治疗人恶性脑胶质瘤、黑色素瘤的番荔枝种子提取物的制备方法及其产品。式Ⅰ、式Ⅱ和式Ⅲ所示化合物以及本发明所述制备方法制备得到的提取物(包括有效部位)对脑胶质瘤和黑色素瘤具有高效杀伤作用。尤其是式Ⅰ所示化合物对脑胶质瘤U87‑MG的IC50值仅为0.4044nM，对黑色素瘤SK‑MEL‑28的IC50值仅有0.5152nM，而对其他多数肿瘤的IC50往往在1uM‑100uM之间，相差三个数量级以上，显示出对脑胶质瘤U87‑MG和黑色素瘤SK‑MEL‑28的选择性和高效杀伤作用。
摘要（英）：

The invention provides application of compound of any one or more of a formula I, a formula II and a formula III for the preparation of a medicament for treating brain malignant gliomas or melanoma and belongs to the technical field of tumor medicines. The compound shown in the formula I, the formula II and the formula III is a monomer ingredient in an annona squamosa total lactones extract. The invention further provides a method for preparing an annona squamosa seed extract for treating human brain malignant gliomas or melanoma and a product thereof. The compound shown in the formula I, theformula II and the formula III and the extract (including effective parts) have an efficient killing effect on the brain malignant gliomas or melanoma. Particularly, the compound shown in the formulaI has an IC 50 value of only 0.4044 nM for brain malignant gliomas U87-MG, and an IC50 value of only 0.5152 nM for melanoma SK-MEL-28, while the IC50 for most other tumors is often between 1uM and 100uM, and the difference is more than three orders of magnitude, showing a selective and efficient killing effect on brain malignant gliomas U87-MG and melanoma SK-MEL-28.

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