The invention discloses pseudo-ginseng granule medicine materical crude slices and a preparation method thereof, and belongs to the field of traditional Chinese medicine materical crude slices. The slices are prepared from, by weight, 50-70 parts of pseudo-ginseng, 10-20 parts ofmaythorn, 10-20 parts of rhizoma gastrodiae, 10-20 parts of salvia miltiorrhiza, 10-20 parts of dendrobeand 15-30 partsof stevia. The preparation method comprises the steps ofboiling the maythorn, the rhizoma gastrodiae, the salvia miltiorrhiza and the dendrobe,concentrating a filtrate, pulverizing the pseudo-ginsengand the steviainto a nanometer order, mixing with the filtrate, and then spraying and granulating to obtain the slices. The pseudo-ginseng granule medicine materical crude slices are added with the maythorn, the rhizoma gastrodiae, the salvia miltiorrhiza, the dendrobe and the stevia to balance nutrients and form a synergistic effect with the pseudo-ginseng, can also neutralize a taste, improve the taste of the whole pseudo-ginseng,improve the immunity, and promote the metabolism, after homogenization mixing is conducted, spraying and drying are conductedto forma granule shape, and the slicesdissolvequickly, are convenient to drinkandhave a better taste.