The invention discloses a method for driving a microfluidic chip, and a device and a micro-fluidic system thereof. In the method, the first electrode is controlled to conduct with the first power supply end through the first switch circuit connected with the first electrode which is currently loaded with liquid drops, and control the first electrode to conduct with the second power supply end fora second time period after the first electrode is controlled to conduct with the first power supply end for a first time period, and continuously control the first electrode and the second power supply ends to be in a disconnected state after the second time period. As the first electrode and the second power supply end can be controlled to conduct for a second time period, charge release is realized; and then control the first electrode to be in a disconnected state with both power supply ends so that partial charge can be left on the first electrode. Therefore, compared with relevant technologies, the method can reduce the electric potential difference between the two adjacent electrodes, thereby avoiding the phenomenon that the two adjacent electrodes are prone to high-voltage breakdowndue to large electric potential difference.