The invention discloses antibacterial silane polyether glue. The glue is mainly prepared from silane-modified polyether resin, a filler, a solvent, a reinforcing agent, a light stabilizer, an antioxidant, a dehydrating agent, a catalyst, a coupling agent and an antibacterial agent. The phosphoric-acid complex-salt antibacterial agent high in compatibility with silane polyether glue is prepared, and modified polysiloxane (a fatty acid substance) with high surface energy is introduced into the silane polyether glue, so that the surface energy of the silane polyether glue is effectively improved,and the bonding performance is improved. The invention also discloses a preparation method of the antibacterial silane polyether glue, and the method of the antibacterial silane polyether glue is simple and suitable for popularization.