The invention discloses a triazine silk fibroin modified polycaprolactone nano-fiber stent and a preparation method thereof. Triazine silk fibroin is mainly synthesized from silk fibroin and melamine,then the triazine silk fibroin and polycaprolactone are dissolved in an organic solvent together, and the nano-fiber stent is prepared after high-pressure electrostatic spinning. By adjusting the mass ratio of the triazine silk fibroin to the polycaprolactone, the nano-fiber stent with different physical, chemical and bioloical properties can be obtained. The experiment result shows that the nano-fiber stent has a 3D network structure similar to an extracellular matrix and good mechanical strength, hydrophilia, hydrophobicity and biocompatibility, and the property requirements of biomedical materials can be met. The preparation method is low in cost and low in environmental pollution, and has large application potential in the actual production process.