The invention relates to a large centralized comprehensive power heating system and a combined operation optimization method thereof. The system comprises municipal electric energy, a wind driven generator, photovoltaic equipment, a power storage device, an energy station system, a solar heat exchange system and a heat storage device; the municipal electric energy, the wind driven generator and the photovoltaic equipment are connected with the power storage device and the energy station system, and supply power to the same; the solar heat exchange system uses solar energy to provide heat energy; the energy station system is connected with the heat storage device, and provides heat and living water to buildings; and the solar heat exchange system is used as a supplement of the energy station system to provide the heat and the living water to the buildings. Such power use characteristics as power grid peak-valley characteristics and natural environments are combined; and through adjustment of the working intermittence of the wind driven generator, the photovoltaic equipment, the solar heat exchange system, the power storage device and the energy station system, the flexible transition is realized, the parallel optimal operation of multiple types of power heating systems is realized, and the effects of energy conservation and emission reduction are achieved.