The invention provides a power grid planning design scheme generation method and device supporting multi-person collaborative operation. The method for the client side comprises the steps that under the constraint of meeting the planning annual boundary condition, superposing a power grid planning reference grid frame and a locally-stored power transmission and transformation project, and forminga preliminary power grid planning design scheme; Carrying out power grid safety and stability analysis on the preliminary power grid planning and designing scheme, and screening out the power grid planning and designing scheme meeting the power grid safety and stability indexes as a checked power grid planning and designing scheme; And carrying out economic and technical index evaluation on the checked power grid planning and design scheme, and determining the design scheme with the optimal economic and technical index as a to-be-reviewed power grid planning and design scheme. According to thepower grid planning design scheme generation method and device provided by the invention, planning reference grid frame data is managed in a unified manner, power transmission and transformation projects and power grid planning design schemes determined at all stages are shared, multi-person collaborative operation is facilitated, and scientificity and efficiency of power grid planning work are improved.