The invention discloses a DC line breakage protection method of a multi-end flexible DC power distribution system. With regard to different running modes of open loop and closed loop of the multi-endflexible DC power distribution system, the fault characteristic thereof during a DC line breakage fault is analyzed, on the basis, the difference between the fault level and the non-fault level is further amplified by taking sum and difference of currents of a fault level circuit and a non-fault level circuit as division, and the purpose of reliably identifying the fault level circuit is achieved.The DC line breakage protection method is applicable to a condition that the DC line breakage fault occurs in the multi-end flexible DC power distribution system under different running mode, the situation that line breakage protection is difficult to achieve due to unobvious line breakage fault characteristic is prevented, and rapid fault identification and pole selection can be achieved according to local measurement information.