The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system (100) comprises a warehouse facility (210), a hydration facility (220), and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility (210) and hydration facility (220) are comprised in the macro structure (200). Each biopharmaceutical manufacturing facility is comprised in a respective micro node (300), and a control facility (230) in the macro structure (200) is configured tocontrol interoperability of the macro structure (200) and the micro nodes (300) by means of a network spine interconnecting the macro structure (200) with each micro node (300).