The invention relates to a five-axis machine tool. The five-axis machine tool comprises a base, a chassis arranged on the base, an installation part which is rotatably arranged on the chassis and usedfor fixing a to-be-machined piece, a slide way arranged on the base, a first guide block which can be slidably arranged on the slide way in the horizontal direction, a second guide block which can beslidably arranged on the first guide block in the vertical direction, a tool magazine and a clamping piece, wherein the tool magazine comprises a tool frame and a driving piece, the tool frame is rotatably arranged on the base and provided with stations, the stations are used for storing tools, and the driving piece drives the tools on the stations to move up and down in the vertical direction; and the clamping piece is arranged on the second guide block and clamps the tools to enable the to-be-machined piece to be machined through the tools. The tool magazine of the five-axis machine tool isconveniently arranged, and the tools can be taken conveniently.