The embodiment of the invention provides a driving method of a display panel, a compensating circuit and a device, and a display device. Since the method can output a data signal generated based on acompensation gray scale corresponding to an initial gray scale to pixels in at least one display area of a first display area and a second display area, an absolute value of a brightness difference value of the two display areas can be smaller than or equal to a difference threshold, that is, the display brightness difference between the two display areas is small. The display panel has good display uniformity.