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发明公开
CN109674782A 紫番茄花青素在调控铬诱导的LMH细胞自噬中的应用 有权

紫番茄花青素在调控铬诱导的LMH细胞自噬中的应用
摘要：
本发明公开了紫番茄花青素在调控铬诱导的LMH细胞自噬中的应用。本发明首次发现Cr(VI)可显著诱导LMH细胞中自噬相关蛋白(Beclin1和LC3II/I)，ER应激相关蛋白(GRP78和PERK)和COX-2表达，抑制通路蛋白mTOR和自噬相关蛋白P62的表达；而紫番茄花青素(PTA)可以缓解Cr(VI)诱导的上述蛋白表达量的变化，证明紫番茄花青素可以显著改善Cr(VI)诱导的LMH细胞自噬和内质网应激，为花青素介导的保护作用的分子机制提供了基础，有利于重金属引起的自噬的调节药物的开发研究。
摘要（英）：

The invention discloses an application of purple tomato anthocyanins in regulating chromium-induced autophagy of LMH cells. The invention discovers for the first time that Cr (VI) can significantly induce the expressions of autophagy-related proteins (Beclin1 and LC3II/I), ER stress-related proteins (GRP78 and PERK) and cyclooxygenase-2 (COX-2) in LMH cells, and inhibit the expressions of pathwayproteins mammalian target of rapamycin (mTOR) and autophagy-related protein P62, while purple tomato anthocyanins (PTA) can alleviate the changes of the expression quantity of the proteins induced byCr (VI), which proves that purple tomato anthocyanins can significantly improve the autophagy and endoplasmic reticulum stress of LMH cells induced by Cr (VI) to provide a basis for the molecular mechanism of anthocyanins-mediated protection effect and to be conducive to the development and research of heavy metals-caused autophagy regulation drugs.

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