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发明公开
CN109674801A 组合 审中-实审

组合
摘要：
一种组合，所述组合包括17α-羟化酶/C17,20裂解酶抑制剂，例如(3β)-17-(吡啶-3-基)雄-5,16-二烯-3-醇或其药学上可接受盐或酯，和AKT抑制剂，例如N-{(1S)-2-氨基-1-[(3-氟苯基)甲基]乙基}-5-氯-4-(4-氯-1-甲基-1H-吡唑-5-基)-2-噻吩甲酰胺或其药学上可接受盐，以及可任选的额外抗肿瘤剂；含有其的药物组合物和使用这类组合及组合物治疗病症的方法，在所述病症中抑制17α-羟化酶/C17,20裂解酶和/或抑制AKT是有益的，例如癌症。
摘要（英）：

A combination comprising a 17[alpha]-hydroxylase/C17,20 lyase inhibitor, for example: (3[beta])-17-(pyridin-3-yl)androsta-5,16-dien-3-ol or a pharmaceutically acceptable salt or ester thereof, and anAKT inhibitor, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibitionof 17[alpha]-hydroxylase/C17,20 lyase and/or AKT inhibition is beneficial, e.g., cancer.

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