The invention discloses a method for preparing hexagon panel blank base materials with eucalyptus cores, and belongs to the technical field of panel processing. The method comprises the following steps of drying the eucalyptus cores, and then performing planer sawing to obtain hexagon square strips; applying an adhesive onto the six edges of the hexagon square strips, and then performing hot pressing on the square strips, so as to obtain long flitches; and according to the required thickness, sawing the long flitches off with a horizontal band saw, applying an adhesive onto two sides, attaching eucalyptus veneers, and performing hot pressing, so as to obtain the hexagon panel blank base materials. Through the adoption of the method disclosed by the invention, the utilization rate of the eucalyptus cores is increased; the eucalyptus cores are prepared into hexagon, so that the volume recovery of the eucalyptus cores can be maximized; and the used adhesive is high in adhesion, good in cold resistance and water resistance, firm in used base materials, and free from cracking, and has high intensity.