The invention discloses an air-space-ground integrated measurement and control method for tailings reservoir risk in the technical field of mine safety risk monitoring, the steps including follows: 1.remote sensing satellite photos of different time periods in a mine area are obtained, and then normal libraries and suspected abnormal libraries are screened out, and difference point areas of the suspected abnormal libraries are found out; 2. according to starting threshold condition of unmanned aerial vehicle, the unmanned aerial vehicle is started to conduct low-altitude aerial survey of thesuspected abnormal libraries to obtain two-dimensional spatial data information; 3. according to starting threshold condition of three-dimensional laser, the three-dimensional laser is started to measure the suspected abnormal libraries to obtain three-dimensional spatial data information and establish a three-dimensional spatial model; 4. when the parameters index of the three-dimensional spatialdata information reaches the threshold range, real-time monitoring is started; 5. abnormal indicators are monitored in real time and early alert is issued. The air-space-ground integrated measurement and control method for the tailings reservoir risk realizes the multi-level monitoring of tailings reservoir in a wide range, and obtains the parameters data of the tailings reservoir in time, quantitatively and at low cost, and can alert the risk.