The invention provides a mold profile design method for large component accurate hot forming with assistance of a computer. The mold profile design method comprises the following steps that by takinga component target profile as an initial mold profile, a three-dimensional model is established according to the initial profile, then cooling simulation is performed on the mold with the initial moldprofile from a hot forming temperature of a component to a room temperature to obtain a cooled mold profile, then the cooled mold profile is used as an initial value of subsequent forming springbackcompensation iteration calculation, an initial value which is closer to the optimal solution is determined before the iterative process of the component forming springback compensation based on a mathematical optimization basic idea, then the initial value is iterated, and the purpose of reducing the iterative times is achieved. Compared with a mode by directly taking a component target profile asan iteration calculation initial value, the method can reduce the iterative times by about 50 percent, greatly improves the solving efficiency and saves the precious time of a mold designer; and theadvantage is more obvious especially for a large component.