The invention discloses a degradable drug eluting stent with the surface provided with a hydrophobic structure and a making method, belongs to the technical field of medical apparatus and instruments,and relates to a design and making method of a hydrophobic degradable drug eluting stent with a micro-structure arranged on the surface in application to the field of vascular interventional medicine. The stent structure is composed of a waveform basic support unit, a straight bar connection unit, a left arc connection unit and a right arc connection unit. Uniformly distributed micro columns aremachined on the single face or double faces of the stent by adopting injection molding or extrusion molding which is matched with the laser engraving or 3D printing technology; the stent has the functions of hydrophobicity, drag reduction, biological self-cleaning and the like. A drug elusion coating is processed through a spraying or soaking method. The stent has good supportability and flexibility, the hydrophobic micro-structure on the surface can also effectively slow down the elution effect of blood flow to drugs in the coating, aggregation and adsorption of an extracellular matrix and platelets around the stent are reduced, and then the risk of restenosis in the stent is reduced.