The invention discloses a multi-injection molding process one-time molding method for a high-toughness home appliance panel. The multi-injection molding process one-time molding method is characterized by comprising the following steps of preparing materials for injection molding; inputting relative parameters of the four-stage injection molding process on a control panel of an injection molding machine; pushing a manual/automatic change-over switch on an electric control cabinet to the automatic position; inputting location parameters and pressure holding parameters of a screw rod on a touchinput screen when completion of filling meeting process switching conditions; closing a safety door of the injection molding machine, pressing an on/off switch in an on position to start the injectionmolding machine; and opening a mold and taking out workpieces after completion of injection molding. According to the multi-injection molding process one-time molding method, the injection molding machine is controlled by a PLC to conduct regulation to adopt different injection molding processes at different injection molding stages according to data stored from the control panel of the injectionmolding machine. Meanwhile, compared with a bonded panel, the panel manufactured through multi-injection molding one-time molding has the good integrity and toughness and is not likely to get bent and fall off.