The invention belongs to the field of advanced luminescence materials, and particularly relates to an orange-red fluorescent zinc coordination polymer with mixed ligands, a preparation method of the polymer and an application of the polymer. The polymer takes a single-core cluster [ZnN3(CO2)] (formula VII) and a double-core cluster [Zn2N3(CO2)3(H2O)] (formula VIII) as joints, the joints are connected through organic ligands tpc<-> (formula IV), Hntb2<-> (formula V) and ntb3<-> (formula VI) to form a two-dimensional layered coordination polymerization structure, the color of a crystal sample isorange red under natural light and ultraviolet light of 365 nm, a solid fluorescent spectrum has double emission peaks (578nm and 654nm), the polymer is provided with a typical colored fluorescent material, and a complex aqueous solution has absorption peaks in a visible light area. By the aid of characters and the preparation method of the polymer, the polymer can be used for preparation of novel light-sensitive materials, pigments or coatings and the like, and the polymer has positive significance and values in the aspects of development and application of novel optical materials, related industrial transformation and upgrading and the like.