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发明公开
CN109749968A 一株生物催化合成(R)-1,3-丁二醇的贝莱斯芽孢杆菌菌株及其应用 有权

一株生物催化合成(R)-1,3-丁二醇的贝莱斯芽孢杆菌菌株及其应用
摘要：
本发明提供了一株生物催化合成(R)-1,3-丁二醇的贝莱斯芽孢杆菌菌株及其应用，属于生物催化技术领域。生物催化合成(R)-1,3-丁二醇的贝莱斯芽孢杆菌菌株SWGC31011，Bacillus velezensis，保藏编号为CGMCC No.13354。所述菌株是一种能够以4-羟基-2-丁酮为底物催化合成(R)-1,3-丁二醇的新菌株，该菌株能够表达产生羰基还原酶，通过该菌株能够实现(R)-1,3-丁二醇高纯度的制备，其转化率95％，光学纯度达到100％。使用本发明的菌株进行不对称还原工艺，反应条件温和，节能环保，同时显著提高(R)-1,3-丁二醇的经济效益，具有很好的工业应用前景。
摘要（英）：

The invention provides a bacillus velezensis strain for synthesizing (R)-1,3-butanediol through biological catalysis and application of the strain, and belongs to the technical field of biological catalysis. The bacillus velezensis strain SWGC31011 for synthesizing (R)-1,3-butanediol through biological catalysis is Bacillus velezensis, and the preservation number of the strain is CGMCC No.13354. The strain is a novel strain capable of catalyzing and synthesizing (R)-1,3-butanediol with 4-hydroxy-2-butanone as a substrate. The strain can expressing and producing carbonyl reductase, high-puritypreparation of (R)-1,3-butanediol can be achieved through the strain, the conversion rate is 95%, and the optical purity is 100%. The strain is used for the asymmetric reduction process, reaction conditions are mild, energy is saved, the environment is protected, meanwhile, economic benefits of (R)-1,3-butanediol are remarkably improved, and the strain has good industrial application prospects.

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