The invention discloses a gray-mold controlling pesticide with pyrisoxazole as a main component. The gray-mold controlling pesticide is composed of the pyrisoxazole and fludioxonil. The pyrisoxazole and the fludioxonil are compounded and mixed according to the mass ratio of the pyrisoxazole to the fludioxonil of 1:3, the composition has the obvious synergistic effect on mycelium growth inhibitionof gray mold germs, the field control effect can be 95% or above, the control effect is remarkable, the dosage of the pesticide can be effectively reduced, and the cost is saved. The gray-mold controlling pesticide has the advantages of being efficient, safe, low in cost, capable of achieving reduction applying of the pesticide and the like.