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发明公开
CN109771404A 丁酸在制备预防和/或治疗自身免疫性疾病药物中的应用 无效 - 驳回

丁酸在制备预防和/或治疗自身免疫性疾病药物中的应用
摘要：
本发明提供了丁酸在制备预防和/或治疗自身免疫性疾病药物中的应用，属于自身免疫性疾病治疗技术领域，根据本发明实施例的记载，丁酸预防性干预可显著抑制实验性关节炎的发生发展，使关节炎发病率下降74％，并保护关节滑膜组织免受炎性细胞浸润和侵蚀破坏。丁酸可增加抗炎因子IL-10的表达，同时减少自身抗体anti-CII以及促炎因子IL-6的产生。进一步，丁酸促进关节淋巴结以及肠道派氏结(peyer's patches，PP)Treg细胞分化，并抑制Tfh细胞表达；丁酸还可以下调肠道派氏结生发中心B(germinal center B，GCB)细胞。
摘要（英）：

The invention provides an application of butyric acid in preparing a medicine for preventing and/or treating autoimmune diseases, and belongs to the technical field of autoimmune disease treatment. According to the embodiment of the invention, preventive intervention of butyric acid can obviously inhibit the occurrence and development of experimental arthritis, reduce the incidence rate of the arthritis by 74%, and protect articular synovial tissue from infiltration or erosion damage of inflammatory cells. The butyric acid can increase the expression of anti-inflammatory factor IL-10 while reducing the production of an autoantibody anti-CII and a pro-inflammatory factor IL-6. Furthermore, the butyric acid promotes the differentiation of joint lymph nodes and intestinal tract peyer's patches treg cells, and inhibits the expression of Tfh cells. The butyric acid can also down-regulate B cells of the germinal center of intestinal tract peyer's patches.

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