Provided is a packaging and boxing machine for 1 ml penicillin bottles. A packaging machine base (2) is a frame metal structural piece, a main conveying belt (1) is longitudinally arranged on the leftside of the packaging machine base (2), a defective product station (3), a line-A packaging mechanism (4) and a line-B packaging mechanism (5) are sequentially mounted in the middle of the upper partof the packaging machine base (2) from left to right, a sorting belt (6) is transversely mounted on the packaging machine base (2) and located outside the defective product station (3), the line-A packaging mechanism (4) and the line-B packaging mechanism (5), a vertical bottle indexing mechanism (7) is mounted at the tail end of the main conveying belt (1), and a turnplate receiving and delivering mechanism (8) and a bidirectional guiding chuck (9) are sequentially mounted on the packaging machine base (2) and located above the sorting belt (6). The penicillin bottles are conveyed to the twoindependent packaging mechanisms through the bidirectional guiding chuck, packaging on the two independent stations is achieved through one sorting belt, and packaging efficiency is improved.