The invention discloses a reusable packaging box. The reusable packaging box comprises a box body and an upper cover, wherein zipper are arranged at the position of the edge of the top of the box body, one end of each zipper is connected with a zipper in a meshed mode, the upper and lower sides of the box body are symmetrically disposed with an upper cover and a lower cover with respect to a horizontal center line of the box body, and the upper cover and the lower cover are connected with the box body in a closed mode through the zipper. According to the reusable packaging box, the upper coverand the lower cover are locked with the box body through the zipper, and the upper and lower C-shapes are presented; by means of operating the zipper and the zipper to work cooperatively, multiple times of opening and closing of a turnover box can be realized, the adhesive tape is not needed, and the turnover box can be repeatedly used; the lower cover is closed by using the zipper, and under thecondition that the upper cover is not opened, the other parts of the box cannot be opened, and a sealing strip is attached to the zipper on the inner side of the upper zipper under the necessary condition. If the sealing strip is damaged or the zipper is damaged, it is indicated that the box body has been opened, and the design purpose is to prevent the packaging box from being opened in an unauthorized manner.