The invention discloses a making method of a fluffy super-soft towel. Acrylic fiber and vinylon twisted yarn is adopted for one face of the towel and used as wool warp; hollow cotton yarn is adopted for the other face of the towel and used as wool warp. The method comprises the following steps of 1, weaving, wherein by adopting a four-weft solidification fluffing mode, the dual-face pile loop towel is woven; 2, vinylon fiber removal, wherein the woven towel is placed in hot water of 45-60 DEG C, and vinylon fibers in the acrylic fiber and vinylon twisted yarn are removed; 3, aftertreatment, wherein the bath ratio is 1:(8-10), the temperature is 60-80 DEG C, and the treatment time is 35-45 min; 4, softening, wherein the bath ratio is 1:(8-10), the temperature is 40-50 DEG C, and the treatment time is 20-40 min; 5, drying, wherein airflow is adopted for drying, and the drying temperature is 125-140 DEG C. The towel made through the making method is light, soft, thermal, healthy, comfortable and particularly suitable for old people and children to use.