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发明公开
CN109789161A 用于增加血浆中尿苷浓度的产品和方法 有权

用于增加血浆中尿苷浓度的产品和方法
摘要：
本发明涉及可溶性钠在制备组合物或试剂盒中的用途，通过口服联合给予可溶性钠和尿苷，所述组合物或试剂盒在哺乳动物、优选人类中用于(治疗性地)改善和延长血浆尿苷水平和尿苷的组织利用度，和/或用于治疗或预防受损的血浆尿苷水平和尿苷的组织利用度，和/或用于预防/治疗与受损的尿苷的血浆和组织利用度有关的病症，其中可溶性钠与尿苷的摩尔比为大于1∶1，优选大于1.5∶1，更优选大于2∶1，甚至更优选至少2.5∶1，甚至更优选至少2.8∶1，更优选3∶1-15∶1，最优选为3∶1-10∶1，特别是3∶1-5∶1。
摘要（英）：

The invention pertains to the use of soluble sodium in the manufacture of a composition or kit of parts for (therapeutically) improving and prolonging blood plasma uridine levels and tissue availability of uridine, and/or for treating or preventing impaired blood plasma uridine levels and tissue availability of uridine, and/or for preventing/treating disorders associated with impaired blood plasmaand tissue availability of uridine, in a mammal, preferably a human being, by orally co-administering soluble sodium and uridine in a molar ratio of soluble sodium to uridine of more than 1:1, preferably more than 1.5:1, more preferably more than 2:1, even more preferably at least 2.5:1, even more preferably at least 2.8:1, more preferably 3:1-15:1, most preferably 3:1-10:1, particularly 3:1-5:1.

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