The invention discloses a synthesizing method of an isoamylene-based chalcone derivative and application of the isoamylene-based chalcone derivative in pharmaceutical industry. The derivative involvedin the method is synthesized in the steps that 1, a compound 1 and a compound 2 are placed in a first organic solvent, an acid-binding agent is added, and a reaction is carried out under the heatingcondition to obtain a compound 3; 2, the compound 3 is placed in a second organic solvent for a reaction under the conditions of atmosphere protection and heating to obtain a reaction material, and the production material is steamed to remove the solvent, residues are subjected to silica-gel column chromatography to obtain a compound 4; 3, the compound 4 and a compound 5 are placed in a third organic solvent for a reaction in a strong acid or strong base environment under the heating condition or under the condition without heating, and a crude target compound product is obtained. Through theexperiments of the inventor, it is shown that the isoamylene-based chalcone derivative has a high activity of resisting Abeta1-42 self-aggregation and is low in toxicity to nerve cells, part of the compounds have a chelating ability to metal ions and have selectivity to metal chelation.