The invention relates to the technical field of medicine, in particular to a Sabia parviflora Wall. ex Roxb. alkaloid compound, a preparation method, application and composition thereof. The structureof the Sabia parviflora Wall. ex Roxb. alkaloid compound is described in the specification. The invention also provides a preparation method of the QFTA compound, and application of the QFTA compoundin preparation of a drug or health product for preventing and treating fatty liver injury. The pharmacological study shows that the QFTA compound provided by the invention can significantly reduce the increase in content of lipid droplets in normal human liver cells LO2 caused by fatty acids. The increase in LDL-C/HDL-C, ALT, and AST levels induced by high-fat diet (HFD) in mice is reduced, indicating the inhibition effect on lipid accumulation in liver cells is obvious. The compound is expected to be developed into the novel drug or health product for preventing and treating the fatty liverinjury disease.