The invention discloses a device for prefabricating holes in a fracture-vug type carbonate rock physical simulation fracture experiment. A soluble medium is arranged in a thin film storage body; a first end of a connection rope is connected with a frame type cover plate, and a second end of the connection rope is connected with the thin film storage body. In use, the heights and the directions ofthe to-be-prefabricated holes are determined first, and the thin film storage body is lowered down through the connection rope; concrete is poured, after a concrete block is solidified, sample drilling is conducted so as to dissolve and discharge the soluble medium in the thin film storage body, and the holes with the required heights and directions are prefabricated in the concrete block withoutpressure. The device has a good guiding significance to tentatively explore how the holes are connected.