The invention discloses a high-pressure rotary spraying soil remediation process. The high-pressure rotary spraying soil remediation process comprises the steps of marking and drilling, guide hole processing, liquid agent rotary spraying and hole sealing. The high-pressure rotary spraying soil remediation process has the advantages of being high in dispersion of remediation agent and uniform in mixing. The invention discloses a device of the high-pressure rotary spraying soil remediation process. The device comprises a guide hole platform and a rotary spraying platform. The device performs drilling treatment on a guide hole in a lifting mode, thereby being convenient to operate; after hole drilling is completed, a winch controls to arrange a chain type sliding frame downwards into a hole,and the chain type sliding frame is in a chain type structure composed of a plurality of sliding frame sections, thereby being convenient to arrange inside the hole and meanwhile achieving loading effects on a high-pressure agent supply hose and a compressed air hose, and further facilitating continuous uplifting and rotary spraying a remediation agent rotary spray nozzle and a compressed air rotary spray nozzle during a working process and being simple and convenient to operate.