The invention discloses a headquarter and branch integration multi-level scheduling optimization method. The method comprises the steps: Step 1, making basic data preparations, wherein the basic datapreparation comprises national dispatching preparation, branch dispatching preparation and provincial dispatching preparation; Step 2, respectively compiling respective constraint and boundary conditions for countries, divisions and provinces; Step 3, performing overall calculation on the national dispatch plan on the panoramic information by the national dispatch; Step 4, performing iterative adjustment between the national dispatch and the provincial dispatch to realize multi-stage dispatch optimization; And step 5, performing result display and return: returning the calculated headquartersand subdivisions integrated multi-level scheduling optimization result to the national, subdivisional and provincial scheduling institutions. According to the method, repeated iteration of a scheduling plan compiled in a current national, provincial and provincial serial iteration mode is reduced, and the capability of coordinated scheduling among national, provincial and multi-level scheduling and the resource overall optimization effect are enhanced.