The invention discloses a self-adaptive selection method for RDMA application transmission parameters in a data center. The method comprises the following steps: step (1), analyzing and collecting application characteristics and server resource states related to RDMA application transmission parameter selection; (2) constructing an RDMA transmission parameter combination selection decision tree model based on application characteristics and server resource states, and adaptively selecting an optimal RDMA transmission parameter combination for different applications; and (3) packaging the decision tree model obtained in the step (2) and the parameter selection process of the RDMA communication programming into a universal API for application. According to the method, an available RDMA transmission parameter combination is constructed and applied through theoretical analysis and experiments; an RDMA transmission parameter combination selection decision tree model is established accordingto the application characteristics and the server resource state, and optimal RDMA transmission parameter selection is provided for the application, so that the performance of the RDMA application isoptimized, meanwhile, the RDMA application development difficulty and development period are reduced, and the innovation of a novel delay-sensitive application of a data center is enabled.