The invention relates to the technical field of electric power operation and maintenance, and particularly discloses a multifunctional metering operation and maintenance tool box comprising a first box body, a second box body, a first USB connector, a first RS232 connector, a first test plier connector and a second test plier connector. The second box body is located below the first box body. A containing groove is formed in the second box body. The first USB connector is fixed to the groove bottom of the containing groove and is used for being connected with a handheld computer. The first RS232 connector is fixed to the groove bottom of the containing groove and is electrically connected with the first USB connector. The first RS232 connector is used for being connected with a meter reading controller. The first test plier connector is fixed to the groove bottom of the containing groove and is used for being connected with the meter reading controller. The second test plier connectoris installed on the side face of the second box body and is electrically connected with the first test plier connector. The multifunctional metering operation and maintenance tool box can effectivelysolve the problems that traditional metering operation and maintenance work tools are various in type and messy in wiring.