The invention relates to the technical field of flyknit uppers, in particular to a TPU flyknit upper. TPU yarn is used for being knitted into a semi-finished flyknit upper, then, antibacterial agent immersion treatment is performed, the surface of the upper is coated with a polyurethane coating, and the TPU flyknit upper is obtained. The TPU yarn has the advantages of being high in elasticity andsmooth, the upper formed by TPU knitting has the pressing-free basic condition, then, the antibacterial performance is achieved through immersion treatment of the antibacterial agent, the coated polyurethane coating has the moisture-permeable waterproof performance, and the obtained upper has the great market advantage.