The embodiment relates to a photoelectronic interface of a multi-mode analyte sensor which is used along with an implantable medical device. The embodiment comprises the implantable medical device. The implantable medical device comprises a first chemistry sensor, wherein the first chemistry sensor comprises an optical stimulating assembly; the optical stimulating assembly comprises one or more ofa first visible spectrum emitter, a second visible spectrum emitter, a near infrared (NIR) emitter and an ultraviolet emitter, and can also comprise an optical testing assembly and a multi-mode sensing element; the optical testing assembly comprises a color comparison response detector and a photoluminescence response detector; and the multi-mode sensing element comprises a color comparison responding element specific to a first chemical analyte and the photoluminescence response element specific to the second chemical analyte. The invention further comprises other embodiments.