The invention discloses a 220 kV two-electricity two-charge direct-current system uninterruptible replacement method. The method comprises the steps of carrying out a switching operation, transferringa load of a 2 # direct current system to a 1 # direct current system, and dismantling an original 5P direct current charging cabinet II and an original 6P accident illumination switching cabinet; installing a new 2 # direct current charging cabinet and a new 3 # direct current feeding cabinet; transferring the load of an original 4P direct current feeding cabinet II; installing a new 4 # direct current feeding cabinet; dismantling an original 3P direct current contacting cabinet and installing a new 2 # direct current feeding cabinet; dismantling an original 2P direct current feeding cabinetI and dismounting an original 1P direct-current charging cabinet I; and installing a new 1 # direct current feeding cabinet and a new 1 # direct current charging cabinet, and carrying out debugging. According to the 220 kV two-electricity two-charge direct-current system uninterruptible replacement method, under the condition of no power failure, a new direct-current system can be installed in anin-situ mode by replacing the two-electricity two-charge direct-current system, and a bridge system, namely a temporary direct current system, is omitted, so that a new system is directly replaced, alarge amount of manpower and material resources are saved, the risk of a power grid is reduced, and the power failure time is shortened.