The invention relates to dressing for craniocerebral trauma and a preparation method of the dressing. The dressing for craniocerebral trauma comprises a fixed layer, a backing layer as well as a waterabsorption layer and a drug layer which are arranged on the backing layer at an interval from outside to inside sequentially, wherein the drug layer comprises kaempferol-3-O-rhamnopyranoside, and a matrix of the drug layer is selected from alginate gel, cellulose gel, chitosan gel and the like. The dressing for craniocerebral trauma has the effect of promoting wound healing, and the effect of promoting wound healing is better when the matrix of the drug layer is chitosan gel containing chitosan oligosaccharide.