The invention discloses medical toothpaste squeezing equipment with a good fixing effect. The medical toothpaste squeezing equipment comprises a storage seat, a front face plate and a rear face plateare fixed to the front end face and the rear end face of the storage seat correspondingly, a feeding through groove is formed in the center of the front face plate, a tail fixing device is arranged inthe rear face plate, an upper face plate is arranged on the upper part of the storage seat, a squeezing device is slidably arranged in the upper face plate and comprises a sliding seat, the sliding seat is connected to a lead screw in a threaded mode and sleeves a guiding rod, a bent lifting plate is arranged at the center of the sliding seat in an inserted mode, and a squeezing roll shaft is arranged on the lower part of the bent lifting plate. The medical toothpaste squeezing equipment has the advantages that through a limiting device on the front part and the fixing device and an anti-loosing device at the tail part, toothpaste can be fixed in the medical toothpaste squeezing equipment firmly and can further be squeezed for multiple times in different degrees, waste is reduced, and byarranging two infrared sensors to simultaneously sensing a toothbrush head, it can be effectively ensured that the toothpaste can be accurately squeezed onto a brush.