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发明公开
CN109922828A 使用具有降低了的分子量的PRP的Hib结合疫苗的制造方法 审中-实审

使用具有降低了的分子量的PRP的Hib结合疫苗的制造方法
摘要：
提供了制备具有高储存稳定性的PRP缀合物的方法、和制造Hib结合疫苗的方法。根据本发明的实施方式的制备PRP缀合物的方法的特征在于，对于PRP与载体蛋白质的偶联反应，通过使用与天然PRP相比具有降低了的分子量的PRP，从而抑制了制备PRP缀合物后的PRP的释放。并且，包含通过所述方法制备的PRP缀合物作为抗原的Hib结合疫苗具有优异的储存稳定性并维持充分的免疫原性。
摘要（英）：

Provided are a method for preparing a PRP conjugate having a high storage stability and a method for producing a Hib conjugate vaccine. The method according to the present invention for preparing a PRP conjugate is characterized in that, in a reaction for coupling PRP with a carrier protein, PRP having a lower molecular weight than native PRP is used so as to suppress the liberation of PRP from the PRP conjugate thus prepared. Similarly, a Hib conjugate vaccine, which comprises the PRP conjugate obtained by the aforesaid preparation method as an antigen, has a high storage stability and retains a sufficient immunogenicity.

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