The invention discloses a core-spun yarn roll packaging device and method. The core-spun yarn roll packaging device comprises a base, a support, a guide rail I, a guide rail II, a feeder, an air pressure cylinder I, an air pressure cylinder II, a film wrapping device, a heat seal device and a welding device. A packaging method of the core-spun yarn roll packaging device comprises the following steps that the air pressure cylinder I and the air pressure cylinder II jack a core-spun yarn roll and convey the core-spun yarn roll to the film wrapping device for film wrapping, the core-spun yarn roll obtained after film wrapping enters the welding device, finally, the core-spun yarn roll is conveyed out through a discharging machine, and core-spun yarn roll film packaging, conveying and outer frame welding are achieved. According to the core-spun yarn roll packaging device and method, a packaging chain is established, core-spun yarn roll plastic film packaging and outer frame welding are finished, the work efficiency is improved, the packaging high efficiency is achieved, the labor intensity of workers is lowered, and the characteristics of automation, simple operation, high efficiency and the like are achieved.